The RARβ2 promoter, containing several high-affinity RA-responsive elements (RAREs), is normally mediated by a dynamic histone deacetylase (HDAC) and histone acetyltransferase (HAT) balance in the presence of physiological levels of RA. However, increased level of histone deacetylation was observed during epithelial cell tumorigenesis and appropriate level of histone reacetylation at RARβ P2 can lead to reactivation of endogenous RARβ2 transcription [44 ].

• Hans, is it perhaps time we had a word with Jeremy?
• Oh, yeah. Jez, listen... Oi oi, tequila slammers!

We demonstrate that if the coefficient of friction is high enough, the sliding localizes within stick-slip pulses, which transform into opening waves propagating at intersonic speed in the direction of sliding or, for high Poisson's ratios, at supersonic speed in the opposite one.

Time is a key success metric.