The mechanistical action of trabectedin on the cell cycle is dependent on its binding to DNA and eventually creating DNA double-strand breaks that alter the normal function of DNA repair and transcription processes resulting in cell cycle arrest.

...some agents can anticipate the predictions which observers make about them sufficiently well to bloody-mindedly falsify them.

I can just remember an old brown-coated man who was the Walton of this stream, who had come over from Newcastle, England, with his son, the latter a stout and hearty man who had lifted an anchor in his day.

The children hung wreaths on all the doors.