最終更新日:2022/12/24
In the present study we sought to investigate the dynamic features and clinical consequences of the thymus-dependent pathway of T cell regeneration after UCBT by analyzing the kinetics of the two major thymotropic cytokines IL-7 and SCF in patient blood, their association with thymic output and quantitative reconstitution of T cell subsets, as well as their prognostic value for clinical outcomes after dUCBT in adult recipients.
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In
the
present
study
we
sought
to
investigate
the
dynamic
features
and
clinical
consequences
of
the
thymus-dependent
pathway
of
T
cell
regeneration
after
UCBT
by
analyzing
the
kinetics
of
the
two
major
thymotropic
cytokines
IL-7
and
SCF
in
patient
blood,
their
association
with
thymic
output
and
quantitative
reconstitution
of
T
cell
subsets,
as
well
as
their
prognostic
value
for
clinical
outcomes
after
dUCBT
in
adult
recipients.