Of patients with known outcomes, 4697 (78%) had viable, serotypeable isolates from a single IPD episode and 3953 (84%) of these were due to the 20 most frequent serotypes including PCV-13 vaccine serotypes.

Perry can undoubtedly be a pain in the backside but in Friends, Lovers and the Big Terrible Thing he wears his big, bruised heart on his sleeve. The overwhelming sense is of a lonely, disappointed man in desperate need of a hug.

There are a few day-flying exceptions such as hummingbird hawk-moths, silver Ys, cinnabars, scarlet tigers and burnets but, in general, knowledge of moths lags behind that of butterflies.

Here he ran out of words, and drew himself up, beard at the high port, shaking his great head while he clasped my hand, and I meditated on the astonishing ease with which strong men of Victorian vintage could be buffaloed into incoherent embarrassment by the mere mention of feminine frailty.