The pitch of middle C is familiar to many musicians.

She was denying herself skittles and beer, and putting up with tea and an old aunt, because she preferred the proprieties of life to its pleasures.

At the closing afternoon, when there was a certain cessation of household cares and a frequent solitariness at teatime in the kitchen, those sea-bordering and empurpled heights would fix her attention, and she would project an inner vision beyond them to desolate sands wherealong her spirit had lamented, and their soleful hush had been borne back to her ears amid the melancholy wave-sounds which traversed watery distances.

According to these alterations, which can be referred to as “central sensitization”, the intrinsic properties of brain stem neurons might change and lead to the decomplexification of respiratory pattern in asthma.