Binimetinib is an oral reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK) 1/2. … Binimetinib inhibits MEK 1/2 downstream from BRAF and halts cancer cell signaling and survival. … Binimetinib is approved in combination with encorafenib, a BRAF inhibitor, for the treatment of unresectable or metastatic melanoma with a BRAF V600E/K mutation, as detected by an FDA-approved test.

[…] Mr. Lawson turned to refasten an up-pulled tent-peg, and to get a cord, and when he turned round again, the mulatto was gone.

Make-believe worseners of human nature and human life, Wertherian, Byronic or à la Musset have given way to the trio of the blackening pen, Flaubert, Zola, Maupassant, and later on their heels comes a wit as brilliant and versatile as Voltaire's, but without Voltaire's hopefulness and faith in humanity — Anatole France. Balzac's work has immensely enriched the intellectual capital of the world, has it made the multitude, the rascal many, happier or better?

This room is a mess; it needs a makeover.