Only a rough sketch will be attempted here—partly because this topic could fill up a book of its own and partly because the author does not have a bookful or even a chapterful of ideas on the subject.

However, hyperghrelinemia is unlikely to arise from leptin resistance, as ghrelin levels are not elevated in obese subjects homozygous for an inactivating LepR mutation.

Don't be a scaredy pant, you got this!

He saw Dr. Simon, a typical French scientist, with glasses, a pointed brown beard, and a forehead barred with those parallel wrinkles which are the penalty of superciliousness, since they come through constantly elevating the eyebrows.