The overreactor develops poor focus while the underreactor has trouble developing empathy. Either pattern will affect how others interact with that person, and thus will affect the neurochemical profile.

And what did you know, you bumpkin! before you came on board this Andrew Miller?

What will it take for me to reach him?

They're all cold. Cold as a witch's kiss. Mean temperatures of 40° Fahrenheit. Never get hotter than 70.