Apart from amphotericin B and sitamaquine that can be considered as control drugs in this screening, clofazimine was the only compound exhibiting activity in the Leishmania donovani intracellular assay as well as an acceptable level of selectivity (SI ~10) (Table 3, S4 Fig ).
Anyhow, here I am […] quite in the mood to revisit one of those Queen Anne country houses where I awoke on the morning after a dance and drowsily observed the discreet man-servant putting a hot-water can into the hip-bath, wondering whether he was expecting me to give him half-a-sovereign or whether five bob would be decent […]
Cololla (1 1/2 inch long) campanulate, ventricose below, compressed laterally, glanduloso-pubescent externally, and there of brilliant red colour, excepting in a broad yellow stripe along the lower side, on the inside yellow, glabrous, and sprinkled with red spots, which are largest on the lower part of the tube, smaller and more crowded on the limb, of which the lobes are subpatent, blunt, unequal, the two lateral ones being rather the largest, and the two upper the smallest and least yellow.
Although developed around the First Cold War of 1947-53, the same debate, about causes and responsibility, elaborated simultaneously rather than sequentially, can be identified with regard to the Second Cold War, of 1979-85.
