English Dictionary

chromothripsis

noun

(genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers.

Chromothripsis is a phenomenon in genetics where a chromosome shatters into multiple fragments and is then reassembled incorrectly.

意味（1）

(genetics, pathology) A multiple of chromosomal rearrangements that is associated with some cancers.

But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes.