最終更新日
：2024/08/06
Lipinski's rule of five
name
(chemistry)
A
rule
of
thumb
stating
that
a
chemical
compound
is
likely
to
be
an
orally
active
drug
in
humans
unless
it
violates
more
than
one
of
these
criteria:
(i)
no
more
than
5
hydrogen
bond
donors
(the
total
number
of
nitrogen–hydrogen
and
oxygen–hydrogen
bonds);
(ii)
no
more
than
10
hydrogen
bond
acceptors
(all
nitrogen
or
oxygen
atoms);
(iii)
a
molecular
mass
less
than
500
daltons;
(iv)
an
octanol-water
partition
coefficient
(log
P)
that
does
not
exceed
5.
意味（1）
(chemistry)
A
rule
of
thumb
stating
that
a
chemical
compound
is
likely
to
be
an
orally
active
drug
in
humans
unless
it
violates
more
than
one
of
these
criteria:
(i)
no
more
than
5
hydrogen
bond
donors
(the
total
number
of
nitrogen–hydrogen
and
oxygen–hydrogen
bonds);
(ii)
no
more
than
10
hydrogen
bond
acceptors
(all
nitrogen
or
oxygen
atoms);
(iii)
a
molecular
mass
less
than
500
daltons;
(iv)
an
octanol-water
partition
coefficient
(log
P)
that
does
not
exceed
5.
復習用の問題
(chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.
正解を見る
Lipinski's rule of five
Lipinski's rule of five is a widely used guideline in drug design.
正解を見る
Lipinski's rule of five is a widely used guideline in drug design.
English Dictionary
項目の編集設定
- 項目の編集権限を持つユーザー - すべてのユーザー
- 項目の新規作成を審査する
- 項目の編集を審査する
- 項目の削除を審査する
- 重複の恐れのある項目名の追加を審査する
- 項目名の変更を審査する
- 審査に対する投票権限を持つユーザー - 編集者
- 決定に必要な投票数 - 1
例文の編集設定
- 例文の編集権限を持つユーザー - すべてのユーザー
- 例文の削除を審査する
- 審査に対する投票権限を持つユーザー - 編集者
- 決定に必要な投票数 - 1
問題の編集設定
- 問題の編集権限を持つユーザー - すべてのユーザー
- 審査に対する投票権限を持つユーザー - 編集者
- 決定に必要な投票数 - 1
