(informal) to be all thumbs, to be very clumsy

(figuratively) to have one's hands tied

(figuratively, informal) to get one's hands dirty

(informal, figuratively) to rub one's hands together (to anticipate something eagerly)

(literally) to wash one's hands / (figuratively, transitive with de) to wash one's hands of something

(figuratively) to sign something enthusiastically, to jump at an opportunity, to grab an opportunity with both hands

(figuratively) to have wandering hands, to be handsy

(figuratively, often derogatory) casually, nonchalantly, in an offhand manner, with a devil-may-care attitude

(figuratively) to pluck up one's courage, to gather up one's courage, to man up

(figuratively, informal) to get one's hands dirty