important / (archaic) difficult, highly troubling / (archaic) seriously ill or injured; grave

An important thing; a serious matter; a valuable thing / (colloquial) trouble

a serious matter

get well soon, take care of yourself

(rare) honorific form of 大事に

care deeply about, treat well. Compare to make much of

(Buddhism) religious zeal; taking great care for the afterlife / fastidiousness, doing one's best; exaggerated or excessive deliberateness