I don't know how to solve this situation.

He ran with all his might.

He overcame difficulties and achieved success.

This situation is disadvantageous for us.

In order to overcome this disadvantageous situation, we must do our best.

He exhausted all his strength to finish the job.

He exhausted himself by working to the limit.

She was devastated by sadness and cried her eyes out all night.

He used every possible means to make the project successful.

He is devoting himself to his work.