This problem is rather annoying to the point of being complicated.

This computer is inconvenient to use.

His request was an inconvenience.

Can you answer this question?

Since my grandmother's health has been deteriorating, I decided to take care of her.

No problem, I will do that job.

That proposal is completely unthinkable.

As a practical question, how are we going to fund this project?

This exam is a matter of life or death for me.

He is viewing that situation as a serious problem.