This problem is rather annoying to the point of being complicated.

This computer is inconvenient to use.

His request was an inconvenience.

Can you answer this question?

Since my grandmother's health has been deteriorating, I decided to take care of her.

A new approach is needed to solve this set of problems.

The main problem with this project is the lack of communication.

This question text is too difficult, it's hard to understand.

This exam is a matter of life or death for me.

He is viewing that situation as a serious problem.