Alternative spelling of お手上げ: throwing up one's hands: giving up, quitting

a hand / a handle, grip / a paw, foreleg / a way of acting, means / (board games) a move, play

difficult / hard, probably impossible

imperfective and stem (or continuative) forms of 上げる (ageru) [ichidan]

honorific prefix to make a word polite

question, problem on homework etc. / a question; a matter (of time etc.) / a problem (something that needs to be dealt with); a trouble / an issue; a matter

(chiefly women's speech) first person singular pronoun: I, me

Alternative spelling of お手上げ: throwing up one's hands: giving up, quitting

already / already the time to do so. shortly, soon. / (chiefly in the negative) any more / Used in exasperation: compare English already / more, further

(colloquial) jeez!, used to express frustration against the addressee; compare use of English already