This new drug has the potential to revolutionize cancer treatment.

Your cooperation is needed for this project.

I need you.

I have confirmed your reservation.

I will confirm your reservation.

The effect of this medicine appears immediately.

We need test subjects to confirm the effects of this new drug.

Could you tell me your reservation date for reaffirmation?

I reaffirmed the plan with him.

Do you understand the necessity of this project?