His actions have a deep connection to all of us.

He is always concerned about his health.

His actions are a matter of concern to all of us.

I became deeply involved in his problem.

He has no involvement in the incident at all.

He is a person who cares about every detail.

He developed a wart on his hand.

He is leading a mediocre life.

His life is very mediocre.

He went to the hospital for the treatment of hemorrhoids.