place of origin, birthplace (of civilization etc.)

(history) Mesopotamia

civilization

origin

originate

to know, be aware of / to learn, acquire, / to be acquainted with, to know (someone) / (colloquial, in the negative) to care in the least about, to be concerned with,

(archaic) antique, old-fashioned / (colloquial) ancient

ancient times, antiquity, remote ages

stem or continuative form of 知る (shiru) [godan]

Alternative spelling of 物知り: a person with broad knowledge, a knowledgeable person