the six holes of the human body, which are the mouth, eyes, ears, nose, anus, and genitals

accomplish, perform, fulfill

role

important, significant

importance, consequence, significance

extraordinary, unusual

emergency

very; extremely / exceedingly; tremendously

human, person, human being / personality, character / (Buddhism) literally meaning: "human society", referring to one of the six realms of reincarnation in Buddhist cosmology.

(archaic) the world in which people live; the world, society