advice

(honorific) to give / (honorific) to do something for me/us

下さる: to give

please give me / (polite, imperative) please do something for me; expressing a request

an elder / a scholar / a teacher or a professor / sensei (Japanese martial arts teacher) / sir, a polite form of address to teachers, doctors, etc.

a title used after the name of teachers, doctors, lawyers, or certain other professionals

(dialect, Hakata) teacher, professor

(chiefly women's speech) first person singular pronoun: I, me

(polite) first-person singular pronoun: I, me

a personal or private matter / (by extension) selfishness