To manage or be in charge of a role or job, in a position of responsibility. / To rule, control, or administer people or things, from a position of authority.

the brain / old form of 腦

thinking; thought process; a train of thought

to think

important, significant

importance, consequence, significance

the largest parts of an organism; organ

(archaic) the world in which people live; the world, society

human, person, human being / personality, character / (Buddhism) literally meaning: "human society", referring to one of the six realms of reincarnation in Buddhist cosmology.

(dated, rare) a place devoid of people