the first of a family line (e.g. John I) / the first position in a succession (e.g. the first presidency) / the first person to hold such a position (e.g. the first president)

big, large, great

a family, a household

to be burdened with, to carry on back or shoulder

Same as above.

he / distal demonstrative, something far off removed from both speaker and listener: that / boyfriend

distal demonstrative, something far off removed from both speaker and listener: that, yon / particularly, male personal third person pronoun: he / by extension from he: boyfriend

he; boyfriend

responsibility / duty

(slang) Alternative form of 大きいお友達