chronic

a headache (pain or ache in the head)

to vex, to trouble, to distress, to afflict, to pester

(medicine) inveteracy; being chronic (a medical condition of extended duration) / (generally): inveteracy; a negative situation of extended duration

he / distal demonstrative, something far off removed from both speaker and listener: that / boyfriend

distal demonstrative, something far off removed from both speaker and listener: that, yon / particularly, male personal third person pronoun: he / by extension from he: boyfriend

he; boyfriend

a target, a mark, a bullseye / an objective, an object (of doing something)

as far as ... is concerned; in terms of ...

chronic disease