set up a business, system, institution, committee, account, etc.

dare, risk, brave, defy / (for an ailment to) afflict / profane (something sacred)

big, large, great

risk (possible, usually negative, outcome) / (computing) RISC

business

new, novel / latest, recent / modern / fresh

(archaic) new, novel / (archaic) latest, recent / (archaic) modern / (archaic) fresh

(obsolete) Alternative spelling of 新たし (aratashi): new, novel

(obsolete) Same as あたらし (atarashi) above

he / distal demonstrative, something far off removed from both speaker and listener: that / boyfriend