(formal, literary) new, novel / fresh / renewed / 灼: efficacious

time / an event, case, occasion, moment; a specific period in time / a time of something / a season / a tense / (literary) the time during which a narrative takes place

challenge (against authority or a higher-ranked person) / (figuratively) try at something

to challenge / (figuratively) to take on the challenge of doing something (especially something one has not done before); to try; to try one's hand at

begin; start; initiate; originate

Alternative spelling of 初めて

conjunctive form of 始める (hajimeru) [ichidan]

to start doing / to begin

to come (toward the speaker/writer) / (specifically, of a sensation) to come and stimulate / (と来たら (to kitara)) when it comes to

next..., coming...