To perform; to do; to conduct oneself; to carry out.

talks; negotiation

negotiate

important, significant

importance, consequence, significance

question, problem on homework etc. / a question; a matter (of time etc.) / a problem (something that needs to be dealt with); a trouble / an issue; a matter

(chiefly women's speech) first person singular pronoun: I, me

(polite) first-person singular pronoun: I, me

a personal or private matter / (by extension) selfishness

(formal) first-person singular pronoun: I, me