(role-playing games, video games) Initialism of non-player character/non-playable character. / (slang, by extension) An ignorant, foolish person who has no will of his or her own.

(Philippines) Initialism of National Power Corporation. / (Philippines) Initialism of National Privacy Commission. / (sports) Initialism of National Paralympic Committee.

(intransitive) To act as an NPC (“non-player character”) in a game.

plural of NPC