A city and unitary authority in Hampshire, in southern England / (historical, usually "The County of Southampton") Hampshire / a barony in the peerage of Great Britain

A tidal estuary, starting in Southampton, Hampshire, England, and flowing into the Solent.

One of 95 counties in Virginia, United States. County seat: Courtland.

(informal) Six artificial food dyes, a mixture of which was studied by researchers at Southampton University (results published in 2007), who found a possible link between these dyes and a sodium benzoate preservative and increased hyperactivity in children consuming them. The dyes are: tartrazine, Allura Red AC, ponceau 4R, Quinoline Yellow WS, sunset yellow, and carmoisine.