The property of being a substance.

Physical matter; material. / A form of matter that has constant chemical composition and characteristic properties. / The essential part of anything; the most vital part.

(rare, transitive) To give substance to; to make real or substantial.

plural of substance

present participle of substance

simple past tense and past participle of substance

(officialese, law) A drug or chemical whose use, possession, manufacture, or sale is regulated or banned by the government.

(zoology) chemical given off from the skin of a fish after injury that warns nearby fish of danger.

An overindulgence in and dependence on a drug or other chemical.

(physics, chemistry) A material with a specific chemical composition.