(figuratively) to set sail, to depart, to sail away, to sail off into the sunset

(transitive) to put into practice

(transitive) to set in motion

(transitive with à) to put an end to, to put a stop to, to clamp down on

(transitive with à) (informal) to put pressure on, to pressure (someone)

(transitive) to take to pieces, to tear to pieces, to tear apart

(transitive) to clear up; set straight

(transitive with à) to set fire to, to set on fire, to set alight, to torch, to ignite / (figuratively, transitive with à) to set on fire, to set alight

to set the table, to lay the table

(transitive) to put in the know, to clue in, to put in the picture