(transitive) to lose (be unable to find) / (transitive, intransitive) to lose (not win) / (reflexive) to get lost

to lose heart, to give up hope

to lose patience, to lose one's patience

to get out of one's depth (to get in a body of water too deep for one to be able to touch the bottom)

to lose one's mind

to be lost in it.

to lose consciousness, to pass out, to keel over, to faint

(informal, figuratively) to lose one's bearings, to be all at sea

(figuratively) to lose face

(figuratively) until one is out of breath, until one is gasping for breath