That event greatly changed his life.

Although he was tired, he continued to work.

Despite my opinion, he pushed through with his own thoughts.

He has no involvement in the incident at all.

His actions have a deep connection to all of us.

He is always concerned about his health.

His actions are a matter of concern to all of us.

I became deeply involved in his problem.

He is a person who cares about every detail.

This is the most difficult case I have ever faced.