(literary) to have lost any sense of shame, to have become impervious to shame, to be shameless

(informal) to have seen it all before, to have survived worse

(figuratively) to have sea legs; to be a good sailor

to hate, to loathe, to have a horror of, to hate with a passion [+ de (someone)]

Used to say that someone's mind is elsewhere.

(figuratively) to have (something) weighing on one's heart

(figuratively) to have a lump in one's throat, to have a heavy heart, to be sad at heart

(figuratively) to have a heavy heart, to be sad at heart

(transitive, figuratively) to have on one's conscience

(figuratively) to be hardhearted, to be heartless, to have no heart